East Syracuse's ZIP area supports 25,589 jobs across 996 businesses, with workers earning an average of $72K per year, 19% above the Onondaga County average. The economy is well-diversified (0.93 index), led by wholesale trade and healthcare. 77.4% of businesses have fewer than 20 employees, and each business employs an average of 25.7 people. Jobs declined 1.2% from the prior year while business count declined 0.9%.