1. States
  2. /California
  3. /San Mateo County
  4. /South San Francisco
CSASan Jose-San Francisco-OaklandMSASan Francisco-Oakland-Fremont#21/65 Population
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South San Francisco is a city in San Mateo County, California, with a population of approximately 66,105.

Population66,105
Median Home Value$1,160,100
Median Income$135,909
Area9.2 sq mi

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Recent News

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NewsAPR 15, 2026

Police investigate threat at South San Francisco elementary school

Police investigate threat at South San Francisco elementary school KRON4

KRON4Read article ↗
NewsAPR 07, 2026

Major biotech company shutting down South San Francisco office

Major biotech company shutting down South San Francisco office KRON4

KRON4Read article ↗
NewsAPR 07, 2026

Biotech giant abandoning South San Francisco research site

Biotech giant abandoning South San Francisco research site SFGATE

SFGATERead article ↗

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